人类病毒学和肿瘤学实验室
研究队伍


图片1.png覃青松 博士,研究员

2010年毕业于美国爱荷华州立大学,获得博士学位,在美国威斯康星大学麦迪逊分校,宾夕法利亚州立大学医学院,和南加州大学从事多年博士后研究。2017年担任人类病毒学与肿瘤学实验室研究员,目前担任实验室负责人。实验室主要从事EBV相关胃癌的流行病学,生物学标志和致癌机制的研究,人巨细胞病毒潜伏调控机制,和HPV相关宫颈癌研究。担任广东省中西医结合实验医学专业委员会常务理事,广东省抗癌协会肿瘤代谢专业委员会委员, 广东省病理生理学会肿瘤专业委员会委员。担任Journal of Virology, Journal of Medical Virology,Infection, genetics and evolution杂志评审。担任博士研究生课程(细胞分子免疫学和分子病毒学)的授课老师。在Journal of Virology, Virology, Journal of Medical Virology,Cancers,Frontiers in microbiology, Frontiers in genetics上发表SCI文章22篇,引用超过1650次。参与两项发明专利。目前主持1项国家自然科学面上项目,1项广东省自然科学项目,2项广东省教育厅项目,1项汕头市科技局项目,参与1项国家自然科学基金面上项目,2项李嘉诚基金会资助项目等(见研究项目)。

发表文章:

1. Mingqian Xu, Jiarui Lin, Shuaibing Yang, Jiahu Yao, Meiyang Chen, Jinfu Feng, Liang Zhang, Li Zhou, Junjie Zhang, Qingsong Qin*. Epstein-Barr Virus-Encoded miR-BART11-3p Modulates the DUSP6-MAPK Axis to Promote Gastric Cancer Cell Proliferation and Metastasis. Journal of Virology, 2023,DOI: 10.1128/jvi.00881-23

2.Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao,Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, and Junjie Zhang*, Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity. Molecular Therapy-Oncolytics 2023 Apr 28;29:61-76. doi: 10.1016/j.omto.2023.04.006.

3.Mingqian Xu, Liang Zhang, Jinfu Feng, Shuaibing Yang, Yixuan Wang, Yuyi Wang, Meiyang Chen, Li Zhou, Junjie Zhang, Qingsong Qin*, Establishment and characterization of two Epstein-Barr virus (EBV)-positive gastric cancer cell lines with epitheliotropic M81 strain undergoing distinct viral and altered cellular expression profiles. J Med Virol. 2022 Dec 8. doi: 10.1002/jmv.28387.

4.Shuaibing Yang #, Qianqian Zhao #, Lihua Tang, Zejia Chen, Zhaoting Wu, Kaixin Li, Ruoru Lin, Yang Chen, Danlin Ou, Li Zhou, *, Jianzhen Xu*, Qingsong Qin*. Whole genome assembly of human papillomavirus by nanopore long-read sequencing. Frontiers in genetics. 2022 Jan 4;12:798608. (JCR Q2, 5 year IF=4.933)

5.Yanyuan Dai, Qingsong Qin, Baixin Chen, Le Chen, Qimeng Sun, Alexandros N. Vgontzas, Maria Basta and Yun Li*. Effects of electrostatic therapy on nighttime sleep and daytime symptoms in patients with chronic insomnia: Evidences from an open label study. Front. Neurosci. 16:1047240. doi: 10.3389/fnins.2022.1047240

6.Yun Li*, Baixin Chen, Zhuoting Hong, Qimeng Sun, Yanyuan Dai, Maria Basta, Xiangdong Tang, Qingsong Qin. Insomnia symptoms during the early and late stages of the COVID-19 pandemic in China: a systematic review and meta-analysis. Sleep Med. 2022 Mar;91:262-272. doi: 10.1016/j.sleep.2021.09.014.

7.Yueyan Liao, Xiangyu Ke, Tianyi Deng and Qingsong Qin*. The Second-Generation XPO1 Inhibitor Eltanexor Inhibits Human Cytomegalovirus (HCMV) Replication and Promotes Type I Interferon Response. Frontiers in Microbiology, 2021; May 3,12: 675112. doi: 10.3389/fmicb.2021.675112. (JCR1区,5 year IF=6.32).

8.Qimeng Sun, Qingsong Qin, Maria Basta, Baixin Chen, Yun Li*. Psychological reactions and insomnia in adults with mental health disorders during the COVID-19 outbreak. BMC Psychiatry. 2021 Jan 8;21(1):19. doi: 10.1186/s12888-020-03036-7.

9.孙启蒙,覃青松,陈柏欣,邵瑞帆,张坚昇,李韵*。新型冠状病毒肺炎流行期非湖北地区民众心理应激、抑郁、焦虑情绪和失眠的调查。中华医学杂志2020 年11月24日第100 卷第43期Natl Med J China,November 24, 2020, Vol. 100, No. 43。

10.Yixuan Wang, Baixin Chen, Yun Li, Lei Zhang, Yuyi Wang, Shuaibing Yang, Xue Xiao, Qingsong Qin*, The Use of Renin-Angiotensin-Aldosterone System (RAAS) Inhibitors is Associated with a Lower Risk of Mortality in Hypertensive COVID-19 Patients: A Systematic Review and Meta-analysis. Journal of Medical Virology. 2021 Mar;93(3):1370-1377. doi: 10.1002/jmv.26625 (JCR Q1,5 year IF=12.203)

11.Yun Li, MD; Qingsong Qin, PhD; Qimeng Sun, MD; Larry D. Sanford, PhD; Alexandros N. Vgontzas, MD; Xiangdong Tang, MD, PhD. Insomnia and Psychological Reactions During the COVID-19 Outbreak in China.Journal of Clinical Sleep Medicine. 2020 Aug 15;16(8):1417-1418. doi: 10.5664/jcsm.8524.

12.Yixuang Wang, Yuyi Wang, Yan Chen, Qingsong Qin*. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. Journal of Medical Virology. 2020 Mar 5. doi: 10.1002/jmv.25748

13.Xingyu Ke, Qingsong Qin*, Tianyi Deng, Yueyan Liao, Shou-jiang Gao*. Heterogeneous Responses of Gastric Cancer Cell Lines to Tenovin-6 and Synergistic Effect with Chloroquine. Cancers (Basel). 2020 Feb 5;12(2). pii: E365. doi: 10.3390/cancers12020365. (JCR分区1区,5 year IF=6.886)

14.Yingsheng Xiao, Qin Xie, Qingsong Qin, Yuanke Liang, Haoyu Lin, De Zeng*. Upregulation of SOX11 enhances tamoxifen resistance and promotes epithelial-to-mesenchymal transition via slug in MCF-7 breast cancer cells. Journal of Cellular Physiology. 2020 Feb 11. doi: 10.1002/jcp.29629.

15.Jinyang Xu, Qingqing Deng, Qingsong Qin, Alexandros N. Vgontzas, Maria Basta, Chanyan Xie, Yun Li. Sleep disorders in Wilson disease: a systematic review and meta-analysis. Journal of Clinical Sleep Medicine. 2020 Feb 15;16(2):219-230. doi: 10.5664/jcsm.8170. Epub 2020 Jan 13.

16.Qingsong Qin*,Yun Li.  Herpesviral infections and anti-microbial protection for Alzheimer’s disease: implications for prevention and treatment. Journal of Medical Virology.2019-08, 91(8): 1368-1377. (JCR Q1,5 year IF=12.203)

17.Qingsong Qin, Matthew Lauver, Saumya Maru, Eugene Lin, and Aron E.             Lukacher. Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells. Virology. 2017, Jan 4; 502: 198-205. (JCR Q3, 5 year IF=3.479)

18.Qingsong Qin, Shwetank, Elizabeth L. Frost, Saumya Maru and Aron Lukacher. Type I interferons regulate magnitude and functionality of mouse polyomavirus-specific CD8 T cells in a viral strain-dependent manner. Journal of Virology. 2016 Apr 29;90(10):5187-99. (selected for spotlight section) (JCR Q1, 5y IF=5.78)

19.Qingsong Qin, Songhee Lee, Ruibing Liang, Robert F. Kalejta. Insertion of a myeloid-active promoter is not sufficient to drive the expression of immediate early gene in undifferentiated cells. Virology. 2014 Jan; 448, 125-132 (JCR Q3,5 year IF=3.479)

20.Qingsong Qin, Rhiannon Penkert, Robert F. Kalejta. Heterologous viral promoters incorporated into the human cytomegalovirus genome are silenced during experimental latency. Journal of Virology. 2013 Sep;87(17):9886-94. (JCR Q1, 5y IF=5.78)

21.Qingsong Qin, Kate Carroll, Craig Hastings, Cathy L. Miller. Mammalian Orthoreovirus escape from host translation shutoff correlates with stress granule disruption and is independent of eIF2a phosphorylation and PKR. Journal of Virology, 2011 Sep; 85(17):8798-8810. (JCR Q1, 5y IF=5.78)

22.T. Cutler, C. Wang, Q. Qin, F. Zhou, K. Warren, K.-J. Yoon,S.J. Hoff, J. Ridpath, J. Zimmerman. Kinetics of UV254 inactivation of selected viral pathogens in a static system. Journal of Applied Microbiology, 2011 May; 111(2).

23.Qingsong Qin, Craig Hastings, Cathy L. Miller. Mammalian orthoreovirus particles induce and are recruited into stress granules at early times post infection. Journal of Virology, 2009 Nov; 83(21):11090-10. (JCR Q1, 5y IF=5.78)


 

人类病毒学与肿瘤学实验室主要成员名单

姓名

学历

职称及职务

研究方向

目前研究内容

覃青松

博士

研究员

病毒肿瘤学

免疫学

见研究项目

Kalim Ullah

博士

博士后

临床实验室诊断学

宫颈癌甲基化早期筛查

许铭倩

硕士

在读博士研究生

肿瘤病毒学

免疫学

EBV阳性胃上皮细胞模型的构建以及研究EBV在胃癌免疫逃逸中的机制

杨帅兵

硕士

在读博士研究生

肿瘤病毒学

基因表达的调控

宫颈癌中HPV整合机制,以及EBV相关胃癌中基因的表观遗传学调控

郝世嘉

硕士

在读博士研究生

生物信息学

免疫学

EBV相关胃癌和HPV相关宫颈癌的肿瘤病毒的测序数据分析

姚甲虎

学士

在读硕士研究生

细胞生物学

EBV膜蛋白棕榈酰化修饰参与胃癌发生发展的机制

陈玫仰

学士

在读硕士研究生

免疫学

EBV相关胃癌来源外泌体参与肿瘤微环境对胃癌进展的作用和机制

吴嘉鑫

学士

在读硕士研究生

免疫学

BS-qPCR检测非甲基化HPV-LCR拷贝数用于宫颈癌筛查的研究。

向芸仪

学士

在读硕士研究生

生物学

基于第三代纳米孔测序技术的EBV编码miRNAs分析

黄燊龙

学士

在读硕士研究生

流行病与卫生统计学

HPV在中老年妇女宫颈癌分布以及特点的流行病学调查